Basis of inquiry: Craniopharyngioma is a brain tumor located near the hypothalamic-pituitary axis. Surgery and conventional photon-based radiation therapy result in long term tumor control; however, survivors are known to have disruptions in patient sleep, endocrine and neurocognitive function, as well as health related quality of life (HRQOL). Proton therapy is a newer form of radiation therapy. Little is known about its effect on patient–reported HRQOL and symptoms when used in the management of craniopharyngioma.
Purpose/Objectives: To describe patient-reported HRQOL and symptoms before and during proton therapy in patients with craniopharyngioma.
Methods: Patients completed the Peds QL v 4 and Peds Brain Tumor (BT) Module prior to and weekly during proton therapy. Higher scores for the Peds QL v 4 and Peds BT Module indicate better HRQOL and decreases in symptoms, respectively. A total of 92 patients (ages 5–18) self–reported Peds QL v4 and Peds BT Module prior to and during 6 weeks of proton therapy.
Findings or Outcomes: Across seven time points, patients reported no change in HRQOL until the final week of proton therapy, at which time there were significant changes in self-reported HRQOL and symptoms. Patients experienced improvement in psychosocial and emotional HRQOL during the final week of proton therapy compared to earlier weeks. Patient-reported physical function did not significantly change during proton therapy and was no different than normative means. Patients did report an increase in nausea symptoms during the final week of proton therapy compared to baseline. There was no notable change in HRQOL during proton therapy until the last week, with patients reporting improved social and emotional functioning. During proton therapy, HRQOL was no different than the normative means. Patients did report an increase in nausea during the last week compared to the 6 previous weeks.
Disclaimer: [1 CH] will be awarded for attending all three paper presentations presented during this timeslot. Partial credit is not available.
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- Belinda Mandrell, PhD RN CPNP