Symptom Assessment and Associated Biomarkers (206)

5:00–6:00 pm Thursday, September 5

Altered sleep and increased fatigue are reported as two of the most distressing symptoms during treatment and into survivorship. Prevalence of disrupted sleep and fatigue have been reported to be higher among patients treated for CNS tumors, those treated with radiation therapy, solid tumors, and Hodgkin Lymphoma; however, changes in sleep and fatigue have been reported across all cancer diagnoses. To elucidate the biological mechanism underlying these symptoms, symptom science has evolved from descriptive studies of symptom occurrence to the measurement of biological processes.

Biomarkers are characteristics that may be objectively measured and evaluated as indicators of normal biological processes, pathogenic processes, and pharmacologic responses. Additionally, biomarkers may be measured to determine the efficacy of a therapeutic intervention. This presentation will review the history, category, and mechanism of selected biomarkers associated with sleep and fatigue. The nurse will be able to describe the types of biomarkers, including physiologic, genomic/genetic, and radiological measurement. The nurse will understand the function of the biomarker and how changes in the biomarker are associated with symptom manifestation. Along with function, the nurse will understand biomarker collection and the optimal timing of collection for specific biomarkers. Lastly, the nurse will have a better understanding of biomarkers that are most responsive to change during an intervention targeted at improving sleep or fatigue.