Children undergoing treatment for acute lymphocytic leukemia (ALL) report co-occurring symptoms of fatigue, sleep disturbances, and depression as a symptom cluster. Physical activity (PA) is essential for development and may influence symptom severity. Nurses often advise patients and families that if they are experiencing distressing symptoms, these will improve with time during the less intensive maintenance phase of therapy.
Using a latent class analysis, we categorized children into a high or low symptom cluster group based on measures at the beginning of maintenance therapy. We then examined their quality of life (QOL) and PA based on their cluster group assignment. This research study examined changes in individual symptoms and QOL over the trajectory of maintenance ALL therapy in children grouped in high or low symptom cluster groups and also explored the influence of PA at the beginning of maintenance on the symptom experience.
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- Mary Hooke, PhD APRN PCNS FAAN CPON®
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