Transfusion of blood products is an essential part of caring for children with benign hematologic disorders, malignant diseases, and those undergoing hematopoietic stem cell transplants. One challenge in pediatric patients is the broad age range for patients that span from neonates to young adults. Recent studies have shown that there is a wide variability in practice among pediatric programs in the indications for transfusions, CMV prevention, and management of patients who become refractory to transfusions.
Although the relative risk of transfusion reaction is low, patients can experience allergic, febrile, septic, and hemolytic reactions. Additional unique challenges include the risk of transfusion associated graft versus host disease in severely immune compromised patients. This presentation will focus on current indications, selection of blood products, and transfusion related complications in pediatric hematology oncology and hematopoietic stem cell transplant patients.
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- Haydar A. Frangoul, MD MS